putative novel insertion sequence elements in prokaryotic genomes

mutationdetection

digIS: in direction of detecting distant and putative novel insertion sequence components in prokaryotic genomes

Background: The insertion sequence components (IS components) symbolize the smallest and probably the most plentiful cell components in prokaryotic genomes. It has been proven that they play a big position in genome group and evolution. To higher perceive their perform within the host genome, it’s fascinating to have an efficient detection and annotation instrument.

This want turns into much more essential when contemplating rapid-growing genomic and metagenomic information. The present instruments for IS components detection and annotation are normally based mostly on evaluating sequence similarity with a database of recognized IS households. Thus, they’ve restricted skill to find distant and putative novel IS components.

Outcomes: On this paper, we current digIS, a software program instrument based mostly on profile hidden Markov fashions assembled from catalytic domains of transposases. It exhibits an excellent efficiency in detecting recognized IS components when examined on datasets with manually curated annotation. The principle contribution of digIS is in its skill to detect distant and putative novel IS components whereas sustaining a average degree of false positives. On this class it outperforms present instruments, particularly when examined on massive datasets of archaeal and bacterial genomes.

Conclusion: We offer digIS, a software program instrument utilizing a novel method based mostly on manually curated profile hidden Markov fashions, which is ready to detect distant and putative novel IS components. Though digIS can discover recognized IS components as effectively, we anticipate it for use primarily by scientists taken with discovering novel IS components.

The Worth of NOTCH2NLC Gene Detection and Pores and skin Biopsy within the Prognosis of Neuronal Intranuclear Inclusion Illness

The scientific manifestations of neuronal intranuclear inclusion illness (NIID) are heterogeneous, and the premortem prognosis is especially based mostly on pores and skin biopsy findings. Irregular GGC repeat expansions in NOTCH2NLC was not too long ago recognized in familial and sporadic NIID. The comparability of diagnostic worth between irregular GGC repeat expansions of NOTCH2NLC and pores and skin biopsy has not been performed but.

On this examine, pores and skin biopsy was carried out in 10 suspected grownup NIID sufferers with scientific and imaging manifestations, and GGC repeat measurement in NOTCH2NLC was additionally screened by repeat primed-PCR and GC-rich PCR. We discovered that 5 instances had ubiquitin-immunolabelling intranuclear inclusion our bodies by pores and skin biopsy, and all of them have been recognized with irregular GGC repeat expansions in NOTCH2NLC, amongst whom 4 sufferers confirmed typical linear hyperintensity at corticomedullary junction on DWI.

Five (5/10) NIID sufferers have been recognized by mixture of NOTCH2NLC gene detection, pores and skin biopsy or mixture of NOTCH2NLC, and typical MRI findings. The diagnostic efficiency of NOTCH2NLC gene detection was extremely in keeping with that of pores and skin biopsy (Kappa = 1). The unexplained headache was firstly reported as a brand new early phenotype of NIID. These findings point out that NOTCH2NLC gene detection is required to be a complement within the diagnose circulation of NIID and likewise could also be used instead technique to pores and skin biopsy particularly in Asian inhabitants.

 

mutationdetection
mutationdetection
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EUR 545
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EUR 233
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EUR 545
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
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EUR 264
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Concentration: 0.2mg/mL
EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
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EUR 405
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
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EUR 513
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Concentration: 0.2mg/mL
EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
BNC682041-100 100uL
EUR 233
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
BNC682041-500 500uL
EUR 545
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
BNC702041-100 100uL
EUR 233
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
BNC702041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF770 conjugate, Concentration: 0.1mg/mL
EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
BNC882041-100 100uL
EUR 233
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
BNC882041-500 500uL
EUR 545
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
BNC942041-100 100uL
EUR 233
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
BNC942041-500 500uL
EUR 545
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
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EUR 233
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
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EUR 545
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
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EUR 233
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
BNCH2041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
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EUR 233
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
BNC802041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF680 conjugate, Concentration: 0.1mg/mL
EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
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EUR 394
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
BNCR2041-250 250uL
EUR 394
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), RPE conjugate, Concentration: 0.1mg/mL
EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
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EUR 394
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
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EUR 233
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
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EUR 545
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EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
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EUR 233
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF680R conjugate, Concentration: 0.1mg/mL
EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody
BNC812041-500 500uL
EUR 545
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF680R conjugate, Concentration: 0.1mg/mL
Epithelial Cell Adhesion Molecule (EPCAM) Antibody (PE)
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
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  • 100 ug
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  • 1 mg
  • 200 ug
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (HRP)
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  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (FITC)
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  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.
Epithelial Cell Adhesion Molecule (EPCAM) Antibody (Biotin)
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  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (FITC)
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  • EUR 523.00
  • EUR 606.00
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  • 100 tests
  • 200 tests
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  • 500 tests
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (APC)
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  • EUR 704.00
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  • EUR 1330.00
  • EUR 495.00
  • 100 tests
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (PE)
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  • EUR 606.00
  • EUR 718.00
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  • 100 tests
  • 200 tests
  • 25 tests
  • 500 tests
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Cow Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
abx516210-96tests 96 tests
EUR 911
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Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
abx516212-96tests 96 tests
EUR 668
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Mouse Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
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EUR 707
  • Shipped within 5-12 working days.
Rat Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
abx516215-96tests 96 tests
EUR 668
  • Shipped within 5-12 working days.
Monkey Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
abx359768-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.
Pig Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
abx361484-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.
Rabbit Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
abx363660-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.
Human EPCAM/ Epithelial cell adhesion molecule ELISA Kit
E0800Hu 1 Kit
EUR 571
Chicken Epithelial cell adhesion molecule, EPCAM ELISA KIT
ELI-04242c 96 Tests
EUR 928
Human Epithelial cell adhesion molecule, EPCAM ELISA KIT
ELI-04243h 96 Tests
EUR 824
Bovine Epithelial cell adhesion molecule, EPCAM ELISA KIT
ELI-04246b 96 Tests
EUR 928
Mouse Epithelial cell adhesion molecule, Epcam ELISA KIT
ELI-04247m 96 Tests
EUR 865
Mouse EPCAM(Epithelial Cell Adhesion Molecule) ELISA Kit
EM1005 96T
EUR 524.1
  • Detection range: 0.078-5 ng/ml
  • Uniprot ID: Q99JW5
  • Alias: EPCAM/17-1A/CD326/GA733-2/gp40/KS1/4/M4S1/TACSTD1/TROP1/17-1A/323/A3/ACSTD1/antigen identified by monoclonal AUA1/CD326 antigen/Cell surface glycoprotein Trop-1/chromosome 4, surface marker(35k
  • Show more
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.047 ng/ml
Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
20-abx151423
  • EUR 7112.00
  • EUR 3792.00
  • EUR 879.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-7 working days.
Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
abx350740-96tests 96 tests
EUR 668
  • Shipped within 5-12 working days.
Chicken Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
abx356953-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.
Human Epithelial Cell Adhesion Molecule (EPCAM) CLIA Kit
20-abx492586
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Please enquire.
Mouse Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
abx254058-96tests 96 tests
EUR 707
  • Shipped within 5-12 working days.
Human Epithelial Cell Adhesion Molecule (EPCAM) CLIA Kit
abx196638-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.
Mouse Epithelial Cell Adhesion Molecule (EPCAM) CLIA Kit
abx196938-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.
Human Epithelial Cell Adhesion Molecule, EPCAM ELISA Kit
DEIA244 5 plates
EUR 1344
Description: The human EPCAM ELISA kit is for the quantitative determination of human EPCAM.
Human Epithelial cell adhesion molecule(EPCAM) ELISA kit
CSB-EL007717HU-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Epithelial cell adhesion molecule (EPCAM) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.
Human Epithelial cell adhesion molecule(EPCAM) ELISA kit
1-CSB-EL007717HU
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Epithelial cell adhesion molecule(EPCAM) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.
EPCAM Epithelial Cell Adhesion Molecule Human Recombinant Protein
PROTP16422 Regular: 20ug
EUR 317
Description: EPCAM Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 267 amino acids (24-265 a.a.) and having a molecular mass of 30.1kDa.;EPCAM is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken)
4-PAB283Ga01
  • EUR 251.00
  • EUR 2576.00
  • EUR 640.00
  • EUR 316.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM (Asp21~Gly260) linked with LEHHHHHH
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM)
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig)
4-PAB283Po01
  • EUR 267.00
  • EUR 2826.00
  • EUR 697.00
  • EUR 338.00
  • EUR 222.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM linked with LEHHHHHH(Gln25~Gln265+(LEHHHHHH))
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM)
Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human)
4-MAB283Hu21
  • EUR 247.00
  • EUR 2516.00
  • EUR 626.00
  • EUR 310.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Gln24~Leu264
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM)
Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
SEB283Hu-10x96wellstestplate 10x96-wells test plate
EUR 4502.43
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Epithelial Cell Adhesion Molecule (EPCAM) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-A
  • Show more
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Epithelial Cell Adhesion Molecule (EPCAM) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
SEB283Hu-1x48wellstestplate 1x48-wells test plate
EUR 458.44
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Epithelial Cell Adhesion Molecule (EPCAM) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-A
  • Show more
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Epithelial Cell Adhesion Molecule (EPCAM) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
SEB283Hu-1x96wellstestplate 1x96-wells test plate
EUR 612.05
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Epithelial Cell Adhesion Molecule (EPCAM) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-A
  • Show more
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Epithelial Cell Adhesion Molecule (EPCAM) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
SEB283Hu-5x96wellstestplate 5x96-wells test plate
EUR 2454.23
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Epithelial Cell Adhesion Molecule (EPCAM) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-A
  • Show more
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Epithelial Cell Adhesion Molecule (EPCAM) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.
Human Epithelial Cell Adhesion Molecule (EPCAM) ELISA Kit
4-SEB283Hu
  • EUR 4553.00
  • EUR 2405.00
  • EUR 613.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
  • Known also as Epithelial Cell Adhesion Molecule elisa. Alternative names of the recognized antigen: CD326
  • TACSTD1
  • EGP
  • KSA
  • M4S1
  • MIC18
  • TROP1
  • HEGP2
  • ESA
  • Epithelial glycoprotein
  • Adenocarcinoma-associated antigen
  • Tumor Associated Calcium Signal
  • Show more
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Epithelial Cell Adhesion Molecule (EPCAM) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species.
Prostate Specific Antigen Std Grade Antigen
VAng-Cr3891-1mg 1 mg
EUR 504
Description: Prostate Specific Antigen Std Grade Antigen, Host/Source: Human Seminal Fluid. The purity is detected by salt precipitation.
ELISA kit for Mouse EPCAM (Epithelial Cell Adhesion Molecule)
E-EL-M0470 1 plate of 96 wells
EUR 534
  • Gentaur's EPCAM ELISA kit utilizes the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse EPCAM. Standards or samples are added to the micro ELISA plate wells and combined with
  • Show more
Description: A sandwich ELISA kit for quantitative measurement of Mouse EPCAM (Epithelial Cell Adhesion Molecule) in samples from Serum, Plasma, Cell supernatant
ELISA kit for Human EPCAM (Epithelial Cell Adhesion Molecule)
ELK1968 1 plate of 96 wells
EUR 432
  • The microtiter plate provided in this kit has been pre-coated with an antibody specific to Epithelial Cell Adhesion Molecule (EPCAM). Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody spec
  • Show more
Description: A sandwich ELISA kit for detection of Epithelial Cell Adhesion Molecule from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.
CLIA kit for Mouse EPCAM (Epithelial Cell Adhesion Molecule)
E-CL-M0286 1 plate of 96 wells
EUR 584
  • Gentaur's EPCAM CLIA kit utilizes the Sandwich- CLIA principle. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to Mouse EPCAM . Standards or samples are added to the micro CLIA plate wells and combined with th
  • Show more
Description: A sandwich CLIA kit for quantitative measurement of Mouse EPCAM (Epithelial Cell Adhesion Molecule) in samples from Serum, Plasma, Cell supernatant
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken), APC
4-PAB283Ga01-APC
  • EUR 351.00
  • EUR 3365.00
  • EUR 935.00
  • EUR 449.00
  • EUR 222.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM (Asp21~Gly260) linked with LEHHHHHH
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with APC.
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken), Biotinylated
4-PAB283Ga01-Biotin
  • EUR 316.00
  • EUR 2526.00
  • EUR 744.00
  • EUR 387.00
  • EUR 221.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM (Asp21~Gly260) linked with LEHHHHHH
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with Biotin.
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken), Cy3
4-PAB283Ga01-Cy3
  • EUR 427.00
  • EUR 4445.00
  • EUR 1205.00
  • EUR 557.00
  • EUR 254.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM (Asp21~Gly260) linked with LEHHHHHH
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with Cy3.
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken), FITC
4-PAB283Ga01-FITC
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM (Asp21~Gly260) linked with LEHHHHHH
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with FITC.
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken), HRP
4-PAB283Ga01-HRP
  • EUR 321.00
  • EUR 2933.00
  • EUR 827.00
  • EUR 405.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM (Asp21~Gly260) linked with LEHHHHHH
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with HRP.
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Chicken), PE
4-PAB283Ga01-PE
  • EUR 301.00
  • EUR 2712.00
  • EUR 768.00
  • EUR 379.00
  • EUR 197.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM (Asp21~Gly260) linked with LEHHHHHH
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Chicken Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with PE.
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig), APC
4-PAB283Po01-APC
  • EUR 376.00
  • EUR 3707.00
  • EUR 1020.00
  • EUR 483.00
  • EUR 232.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM linked with LEHHHHHH(Gln25~Gln265+(LEHHHHHH))
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with APC.
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig), Biotinylated
4-PAB283Po01-Biotin
  • EUR 334.00
  • EUR 2776.00
  • EUR 806.00
  • EUR 412.00
  • EUR 228.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM linked with LEHHHHHH(Gln25~Gln265+(LEHHHHHH))
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with Biotin.
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig), Cy3
4-PAB283Po01-Cy3
  • EUR 459.00
  • EUR 4901.00
  • EUR 1319.00
  • EUR 602.00
  • EUR 267.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM linked with LEHHHHHH(Gln25~Gln265+(LEHHHHHH))
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with Cy3.
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig), FITC
4-PAB283Po01-FITC
  • EUR 320.00
  • EUR 2985.00
  • EUR 836.00
  • EUR 406.00
  • EUR 205.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM linked with LEHHHHHH(Gln25~Gln265+(LEHHHHHH))
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with FITC.
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig), HRP
4-PAB283Po01-HRP
  • EUR 342.00
  • EUR 3229.00
  • EUR 901.00
  • EUR 435.00
  • EUR 217.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM linked with LEHHHHHH(Gln25~Gln265+(LEHHHHHH))
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with HRP.
Epithelial Cell Adhesion Molecule (EPCAM) Polyclonal Antibody (Pig), PE
4-PAB283Po01-PE
  • EUR 320.00
  • EUR 2985.00
  • EUR 836.00
  • EUR 406.00
  • EUR 205.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: EPCAM linked with LEHHHHHH(Gln25~Gln265+(LEHHHHHH))
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Pig Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with PE.
Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human), APC
4-MAB283Hu21-APC
  • EUR 346.00
  • EUR 3284.00
  • EUR 914.00
  • EUR 440.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Gln24~Leu264
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with APC.
Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human), Biotinylated
4-MAB283Hu21-Biotin
  • EUR 312.00
  • EUR 2466.00
  • EUR 729.00
  • EUR 381.00
  • EUR 219.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Gln24~Leu264
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with Biotin.
Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human), Cy3
4-MAB283Hu21-Cy3
  • EUR 420.00
  • EUR 4337.00
  • EUR 1178.00
  • EUR 546.00
  • EUR 251.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Gln24~Leu264
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with Cy3.
Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human), FITC
4-MAB283Hu21-FITC
  • EUR 297.00
  • EUR 2647.00
  • EUR 751.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Gln24~Leu264
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with FITC.
Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human), HRP
4-MAB283Hu21-HRP
  • EUR 316.00
  • EUR 2862.00
  • EUR 809.00
  • EUR 398.00
  • EUR 207.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Gln24~Leu264
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with HRP.
Epithelial Cell Adhesion Molecule (EPCAM) Monoclonal Antibody (Human), PE
4-MAB283Hu21-PE
  • EUR 297.00
  • EUR 2647.00
  • EUR 751.00
  • EUR 372.00
  • EUR 195.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Gln24~Leu264
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Mouse monoclonal antibody against Human Epithelial Cell Adhesion Molecule (EPCAM). This antibody is labeled with PE.
ELISA kit for Human Epithelial cell adhesion molecule (EPCAM)
KTE62402-48T 48T
EUR 332
  • The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of ~40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. Normal epithelia expr
  • Show more
Description: Quantitative sandwich ELISA for measuring Human Epithelial cell adhesion molecule (EPCAM) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human Epithelial cell adhesion molecule (EPCAM)
KTE62402-5platesof96wells 5 plates of 96 wells
EUR 2115
  • The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of ~40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. Normal epithelia expr
  • Show more
Description: Quantitative sandwich ELISA for measuring Human Epithelial cell adhesion molecule (EPCAM) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
ELISA kit for Human Epithelial cell adhesion molecule (EPCAM)
KTE62402-96T 96T
EUR 539
  • The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of ~40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. Normal epithelia expr
  • Show more
Description: Quantitative sandwich ELISA for measuring Human Epithelial cell adhesion molecule (EPCAM) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.
Mouse Anti-Human Ep-CAM/Epithelial Specific Antigen monoclonal antibody, clone JID678
CABT-L2933-100uL500uL 100 uL, 500 uL
EUR 502
Epithelial Membrane Antigen (MUC1) Antibody
20-abx123255
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul
  • Shipped within 5-10 working days.
Epithelial Membrane Antigen (MUC1) Antibody
20-abx121644
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
Epithelial Membrane Antigen (MUC1) Antibody
20-abx133246
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
Epithelial Membrane Antigen (EMA) Antibody
abx022470-02mg 0.2 mg
EUR 940
  • Shipped within 5-10 working days.
Epithelial Membrane Antigen (MUC1) Antibody
abx023797-1mg 1 mg
EUR 843
  • Shipped within 5-10 working days.
Epithelial Membrane Antigen (MUC1) Antibody
abx025382-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.
Epithelial Membrane Antigen (MUC1) Antibody
abx025382-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.
Epithelial Membrane Antigen (MUC1) Antibody
abx020564-1mg 1 mg
EUR 843
  • Shipped within 5-10 working days.
Epithelial Membrane Antigen (MUC1) Antibody
abx020565-1mg 1 mg
EUR 801
  • Shipped within 5-10 working days.
Epithelial Membrane Antigen (MUC1) Antibody
abx020566-1mg 1 mg
EUR 843
  • Shipped within 5-10 working days.
Epithelial Membrane Antigen (MUC1) Antibody
abx020567-1mg 1 mg
EUR 843
  • Shipped within 5-10 working days.
Epithelial Membrane Antigen (MUC1) Antibody
abx020569-1mg 1 mg
EUR 801
  • Shipped within 5-10 working days.
Epithelial Membrane Antigen (MUC1) Antibody
abx020571-1mg 1 mg
EUR 801
  • Shipped within 5-10 working days.

Gene Expression Modifications in a Mannequin Neuron Cell Line Uncovered to Autoantibodies from Sufferers with Traumatic Mind Damage and/or Sort 2 Diabetes

Traumatic mind damage and grownup sort 2 diabetes mellitus are every related to the late prevalence of accelerated cognitive decline and Parkinson’s illness via unknown mechanisms. Beforehand, we reported elevated circulating agonist autoantibodies concentrating on the 5-hydroxytryptamine 2A receptor in plasma from subsets of Parkinson’s illness, dementia, and diabetic sufferers struggling with microvascular problems.

Right here, we use a mannequin neuron, mouse neuroblastoma (N2A) cell line, to check messenger RNA expression adjustments following transient publicity to traumatic mind damage and/or sort 2 diabetes mellitus plasma harboring agonist 5-hydroxytryptamine 2A receptor autoantibodies.

We now report involvement of the mitochondrial dysfunction pathway and Parkinson’s illness pathways in autoantibody-induced gene expression adjustments occurring in neuroblastoma cells. Useful gene classes upregulated considerably included cell dying, cytoskeleton-microtubule perform, actin polymerization or depolymerization, regulation of cell oxidative stress, mitochondrial perform, immune perform, protein metabolism, and vesicle perform.

Gene classes considerably downregulated included microtubule perform, cell adhesion, neurotransmitter launch, dopamine metabolism synaptic plasticity, upkeep of neuronal differentiation, mitochondrial perform, and cell signaling.

Taken collectively, these outcomes recommend that agonist 5-hydroxytryptamine receptor autoantibodies (which enhance in Parkinson’s illness and different types of neurodegeneration) mediate a coordinating program of gene expression adjustments in a mannequin neuron which predispose to neuro-apoptosis and are linked to human neurodegenerative ailments pathways.

Novel Alzheimer’s illness danger variants recognized based mostly on whole-genome sequencing of APOE ε4 carriers

Alzheimer’s illness (AD) is a progressive neurodegenerative illness related to a fancy genetic etiology. Moreover the apolipoprotein E ε4 (APOE ε4) allele, a couple of dozen different genetic loci related to AD have been recognized via genome-wide affiliation research (GWAS) performed primarily in people of European ancestry.

 

Lately, a number of GWAS carried out in different ethnic teams have proven the significance of replicating research that establish beforehand established danger loci and looking for novel danger loci. APOE-stratified GWAS have yielded novel AD danger loci that may be masked by, or be depending on, APOE alleles.

 

We carried out whole-genome sequencing (WGS) on DNA from blood samples of 331 AD sufferers and 169 aged controls of Korean ethnicity who have been APOE ε4 carriers. Based mostly on WGS information, we designed a custom-made AD chip (cAD chip) for additional evaluation on an impartial set of 543 AD sufferers and 894 aged controls of the identical ethnicity, no matter their APOE ε4 allele standing.

Mixed evaluation of WGS and cAD chip information revealed that SNPs rs1890078 (P = 6.64E-07) and rs12594991 (P = 2.03E-07) in SORCS1 and CHD2 genes, respectively, are novel genetic variants amongst APOE ε4 carriers within the Korean inhabitants.

As well as, 9 doable novel variants that have been uncommon in people of European ancestry however frequent in East Asia have been recognized. This examine demonstrates that APOE-stratified evaluation is vital for understanding the genetic background of AD in numerous populations.

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