putative novel insertion sequence elements in prokaryotic genomes

mutationdetection

digIS: in direction of detecting distant and putative novel insertion sequence components in prokaryotic genomes

Background: The insertion sequence components (IS components) symbolize the smallest and probably the most plentiful cell components in prokaryotic genomes. It has been proven that they play a big position in genome group and evolution. To higher perceive their perform within the host genome, it’s fascinating to have an efficient detection and annotation instrument.

This want turns into much more essential when contemplating rapid-growing genomic and metagenomic information. The present instruments for IS components detection and annotation are normally based mostly on evaluating sequence similarity with a database of recognized IS households. Thus, they’ve restricted skill to find distant and putative novel IS components.

Outcomes: On this paper, we current digIS, a software program instrument based mostly on profile hidden Markov fashions assembled from catalytic domains of transposases. It exhibits an excellent efficiency in detecting recognized IS components when examined on datasets with manually curated annotation. The principle contribution of digIS is in its skill to detect distant and putative novel IS components whereas sustaining a average degree of false positives. On this class it outperforms present instruments, particularly when examined on massive datasets of archaeal and bacterial genomes.

Conclusion: We offer digIS, a software program instrument utilizing a novel method based mostly on manually curated profile hidden Markov fashions, which is ready to detect distant and putative novel IS components. Though digIS can discover recognized IS components as effectively, we anticipate it for use primarily by scientists taken with discovering novel IS components.

The Worth of NOTCH2NLC Gene Detection and Pores and skin Biopsy within the Prognosis of Neuronal Intranuclear Inclusion Illness

The scientific manifestations of neuronal intranuclear inclusion illness (NIID) are heterogeneous, and the premortem prognosis is especially based mostly on pores and skin biopsy findings. Irregular GGC repeat expansions in NOTCH2NLC was not too long ago recognized in familial and sporadic NIID. The comparability of diagnostic worth between irregular GGC repeat expansions of NOTCH2NLC and pores and skin biopsy has not been performed but.

On this examine, pores and skin biopsy was carried out in 10 suspected grownup NIID sufferers with scientific and imaging manifestations, and GGC repeat measurement in NOTCH2NLC was additionally screened by repeat primed-PCR and GC-rich PCR. We discovered that 5 instances had ubiquitin-immunolabelling intranuclear inclusion our bodies by pores and skin biopsy, and all of them have been recognized with irregular GGC repeat expansions in NOTCH2NLC, amongst whom 4 sufferers confirmed typical linear hyperintensity at corticomedullary junction on DWI.

Five (5/10) NIID sufferers have been recognized by mixture of NOTCH2NLC gene detection, pores and skin biopsy or mixture of NOTCH2NLC, and typical MRI findings. The diagnostic efficiency of NOTCH2NLC gene detection was extremely in keeping with that of pores and skin biopsy (Kappa = 1). The unexplained headache was firstly reported as a brand new early phenotype of NIID. These findings point out that NOTCH2NLC gene detection is required to be a complement within the diagnose circulation of NIID and likewise could also be used instead technique to pores and skin biopsy particularly in Asian inhabitants.

 

mutationdetection
mutationdetection

Epithelial Specific Antigen (ESA)Ep-CAM (FITC labeled)

MM-1014-15 0.5 ml (0.1 mg)
EUR 158.9

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Mouse Monoclonal Ep-CAM/Epithelial Specific Antigen Antibody

TA327673 1 ml Ask for price

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TA327674 1 ml Ask for price

epithelial specific antigen-251

esa-250 2 ML
EUR 393.75

Mouse Anti-Human Ep-CAM/Epithelial Specific Antigen monoclonal antibody, clone JID678

CABT-L2933-100uL500uL 100 uL, 500 uL
EUR 602.4

Human epithelial specific antigen,ESA ELISA Kit

201-12-1680 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human epithelial specific antigen(ESA) Elisa Kit

EK710933 96 Wells
EUR 0.13

Human epithelial specific antigen(ESA)ELISA Kit

GA-E1696HM-48T 48T
EUR 346.8

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GA-E1696HM-96T 96T
EUR 559.2

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CN-04610H1 96T
EUR 530.4

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EUR 351.6

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EUR 433.2

Human epithelial specific antigen,ESA ELISA Kit

SL0672Hu 96 Tests
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Human epithelial specific antigen,ESA ELISA Kit

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Epithelial Specific Antigen (ESA) Antibody, Concentrate

MAB431C 0.2ml
EUR 415

Anti-Ep-CAM/Epithelial Specific Antigen antibody

STJ16100363 1 mL
EUR 1041.6

Epithelial Specific Antigen, (ESA) Antibody, Ready-To-Use

MAB431P 7ml
EUR 405

Rat Epithelial specific Anti-gen(ESA) ELISA Kit

NSL0570r 96 Tests
EUR 498

Goat Epithelial specific Anti-gen(ESA) ELISA Kit

NSL0783Gt 96T
EUR 528

Human Epithelial specific Anti-gen(ESA) ELISA Kit

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EUR 468

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EUR 528

Canine Epithelial specific Anti-gen(ESA) ELISA Kit

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EUR 528

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EUR 528

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NSL0824Ch 919 T
EUR 528

Guinea pig Epithelial specific Anti-gen(ESA) ELISA Kit

NSL0857Gp 96T
EUR 528

Epithelium Specific Antigen antibody

10R-E126A 50 ug
EUR 473
Description: Mouse monoclonal Epithelium Specific Antigen antibody

EPCAM (untagged)-Human epithelial cell adhesion molecule (EPCAM)

SC118692 10 µg Ask for price

EPCAM (untagged)-Human epithelial cell adhesion molecule (EPCAM)

SC322331 10 µg Ask for price

EPCAM (GFP-tagged) - Human epithelial cell adhesion molecule (EPCAM)

RG201989 10 µg Ask for price

Epcam (untagged) - Mouse epithelial cell adhesion molecule (Epcam), (10ug)

MC203751 10 µg Ask for price

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx338680
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx327226
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx430513-200ul 200 ul
EUR 460.8

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx270202
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx324346
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx331190-100ul 100 ul
EUR 510

Epithelial Cell Adhesion Molecule (EpCAM) Antibody

abx037446-100ug 100 ug
EUR 469.2

Epithelial Cell Adhesion Molecule (EpCAM) Antibody

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20-abx129957
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx176308
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx172278
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx214622
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Epithelial Cell Adhesion Molecule (EpCAM) Antibody

20-abx123431
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx125330
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx232799-100ug 100 ug
EUR 610.8

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

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EUR 493.2

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx242428
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx242433
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx112318
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  • 150 ul
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx159488-100ul 100 ul
EUR 560.4

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

20-abx104775
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx011925-100ul 100 ul
EUR 493.2

Epithelial Cell Adhesion Molecule (EpCAM) Antibody

abx030033-400ul 400 ul
EUR 627.6

Epithelial Cell Adhesion Molecule (EpCAM) Antibody

abx030033-80l 80 µl
EUR 343.2

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx011925-100g 100 µg Ask for price

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx011925-10g 10 µg
EUR 362.5

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abx011925-200g 200 µg Ask for price

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx242428-96tests 96 tests
EUR 250

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx242433-96tests 96 tests
EUR 250

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx270202-1ml 1 ml
EUR 937.5

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abx270202-200l 200 µl
EUR 625

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx037446-1096tests 10 × 96 tests Ask for price

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abx037446-596tests 5 × 96 tests Ask for price

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx037446-96tests 96 tests
EUR 337.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx037447-1096tests 10 × 96 tests Ask for price

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abx037447-596tests 5 × 96 tests Ask for price

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx037447-96tests 96 tests
EUR 337.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx129957-100l 100 µl
EUR 287.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx129957-1ml 1 ml
EUR 850

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx129957-200l 200 µl
EUR 375

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx104775-100g 100 µg
EUR 775

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx104775-20g 20 µg
EUR 275

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx104775-50g 50 µg
EUR 350

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx112318-100l 100 µl
EUR 612.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx137588-01mg 0.1 mg
EUR 225

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx139724-100g 100 µg
EUR 275

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx139725-100g 100 µg
EUR 275

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx019080-1mg 1 mg
EUR 300

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx224065-100tests 100 tests Ask for price

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx224065-200tests 200 tests Ask for price

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx224065-20tests 20 tests
EUR 362.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx239870-100l 100 µl Ask for price

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx239870-50l 50 µl
EUR 350

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx176308-1096tests 10 × 96 tests
EUR 712.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx176308-596tests 5 × 96 tests
EUR 325

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx176308-96tests 96 tests
EUR 262.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx232799-100g 100 µg
EUR 350

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx030033-400l 400 µl
EUR 518.75

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx159488-100g 100 µg Ask for price

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx159488-10g 10 µg
EUR 437.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx159488-50g 50 µg Ask for price

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx172278-1ml 1 ml
EUR 275

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx214622-100tests 100 tests
EUR 350

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx214622-200tests 200 tests Ask for price

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx214622-20tests 20 tests
EUR 250

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx341086-100l 100 µl
EUR 350

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx341086-50l 50 µl
EUR 250

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx349900-96tests 96 tests
EUR 287.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx327226-100g 100 µg
EUR 250

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx327226-50g 50 µg
EUR 187.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx338680-100g 100 µg
EUR 362.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx338680-20g 20 µg
EUR 162.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx338680-50g 50 µg
EUR 250

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx402258-200g 200 µg
EUR 287.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx402504-100g 100 µg
EUR 287.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx324346-100g 100 µg
EUR 250

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx324346-50g 50 µg
EUR 187.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx413459-200l 200 µl
EUR 737.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx413462-200l 200 µl
EUR 462.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx413463-200l 200 µl
EUR 175

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx413764-200l 200 µl
EUR 2150

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx415573-200l 200 µl
EUR 1112.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx415574-200l 200 µl
EUR 512.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody

abx430513-200l 200 µl
EUR 387.5

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNUB2041-50 50uL
EUR 486
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), 1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC702041-100 100uL
EUR 279.6
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF770 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC702041-500 500uL
EUR 654
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF770 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC802041-100 100uL
EUR 279.6
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF680 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC802041-500 500uL
EUR 654
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF680 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC812041-100 100uL
EUR 279.6
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF680R conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC812041-500 500uL
EUR 654
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF680R conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC552041-100 100uL
EUR 279.6
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF555 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC552041-500 500uL
EUR 654
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF555 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC612041-100 100uL
EUR 279.6
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF660R conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC612041-500 500uL
EUR 654
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF660R conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC432041-100 100uL
EUR 279.6
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF543 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC432041-500 500uL
EUR 654
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF543 conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC052041-100 100uL
EUR 279.6
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF405M conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNC052041-500 500uL
EUR 654
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), CF405M conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCA2041-250 250uL
EUR 472.8
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), APC conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCAP2041-100 100uL
EUR 279.6
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCAP2041-500 500uL
EUR 654
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCH2041-100 100uL
EUR 279.6
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCH2041-500 500uL
EUR 654
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCP2041-250 250uL
EUR 472.8
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), PerCP conjugate, Concentration: 0.1mg/mL

EpCAM / CD326 (Epithelial Marker) (EGP40/2041R) Antibody

BNCR2041-250 250uL
EUR 472.8
Description: Primary antibody against EpCAM / CD326 (Epithelial Marker) (EGP40/2041R), RPE conjugate, Concentration: 0.1mg/mL

EPCAM (Myc-DDK-tagged)-Human epithelial cell adhesion molecule (EPCAM)

RC201989 10 µg Ask for price

Epcam (Myc-DDK-tagged) - Mouse epithelial cell adhesion molecule (Epcam)

MR204481 10 µg Ask for price

Human Epithelial cell adhesion molecule (EPCAM)

1-CSB-EP007717HU
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Description: Recombinant Human Epithelial cell adhesion molecule(EPCAM),partial expressed in E.coli

Epcam (untagged ORF) - Rat epithelial cell adhesion molecule (Epcam), (10 ug)

RN214953 10 µg Ask for price

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (PE)

20-abx270964
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  • 100 tests
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (PE)

abx140492-100tests 100 tests
EUR 577.2

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (PE)

abx140492-100g 100 µg
EUR 400

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (PE)

abx139726-100g 100 µg
EUR 400

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (PE)

abx415813-200l 200 µl
EUR 487.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (APC)

20-abx270732
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (HRP)

20-abx335604
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  • 100 ug
  • 1 mg
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  • 20 ug
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (APC)

abx140486-100g 100 µg
EUR 400

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (APC)

abx139727-100g 100 µg
EUR 400

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (HRP)

abx335604-100g 100 µg
EUR 362.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (HRP)

abx335604-20g 20 µg
EUR 162.5

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (HRP)

abx335604-50g 50 µg
EUR 250

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (FITC)

20-abx270500
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Epithelial Cell Adhesion Molecule (EPCAM) Antibody (FITC)

20-abx335605
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  • 100 ug
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  • 50 ug

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (FITC)

abx140496-100tests 100 tests
EUR 510

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (FITC)

abx140496-100g 100 µg
EUR 350

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (FITC)

abx139728-100g 100 µg
EUR 350

Epithelial Cell Adhesion Molecule (EPCAM) Antibody (FITC)

abx335605-100g 100 µg
EUR 362.5

Gene Expression Modifications in a Mannequin Neuron Cell Line Uncovered to Autoantibodies from Sufferers with Traumatic Mind Damage and/or Sort 2 Diabetes

Traumatic mind damage and grownup sort 2 diabetes mellitus are every related to the late prevalence of accelerated cognitive decline and Parkinson’s illness via unknown mechanisms. Beforehand, we reported elevated circulating agonist autoantibodies concentrating on the 5-hydroxytryptamine 2A receptor in plasma from subsets of Parkinson’s illness, dementia, and diabetic sufferers struggling with microvascular problems.

Right here, we use a mannequin neuron, mouse neuroblastoma (N2A) cell line, to check messenger RNA expression adjustments following transient publicity to traumatic mind damage and/or sort 2 diabetes mellitus plasma harboring agonist 5-hydroxytryptamine 2A receptor autoantibodies.

We now report involvement of the mitochondrial dysfunction pathway and Parkinson’s illness pathways in autoantibody-induced gene expression adjustments occurring in neuroblastoma cells. Useful gene classes upregulated considerably included cell dying, cytoskeleton-microtubule perform, actin polymerization or depolymerization, regulation of cell oxidative stress, mitochondrial perform, immune perform, protein metabolism, and vesicle perform.

Gene classes considerably downregulated included microtubule perform, cell adhesion, neurotransmitter launch, dopamine metabolism synaptic plasticity, upkeep of neuronal differentiation, mitochondrial perform, and cell signaling.

Taken collectively, these outcomes recommend that agonist 5-hydroxytryptamine receptor autoantibodies (which enhance in Parkinson’s illness and different types of neurodegeneration) mediate a coordinating program of gene expression adjustments in a mannequin neuron which predispose to neuro-apoptosis and are linked to human neurodegenerative ailments pathways.

Novel Alzheimer’s illness danger variants recognized based mostly on whole-genome sequencing of APOE ε4 carriers

Alzheimer’s illness (AD) is a progressive neurodegenerative illness related to a fancy genetic etiology. Moreover the apolipoprotein E ε4 (APOE ε4) allele, a couple of dozen different genetic loci related to AD have been recognized via genome-wide affiliation research (GWAS) performed primarily in people of European ancestry.

 

Lately, a number of GWAS carried out in different ethnic teams have proven the significance of replicating research that establish beforehand established danger loci and looking for novel danger loci. APOE-stratified GWAS have yielded novel AD danger loci that may be masked by, or be depending on, APOE alleles.

 

We carried out whole-genome sequencing (WGS) on DNA from blood samples of 331 AD sufferers and 169 aged controls of Korean ethnicity who have been APOE ε4 carriers. Based mostly on WGS information, we designed a custom-made AD chip (cAD chip) for additional evaluation on an impartial set of 543 AD sufferers and 894 aged controls of the identical ethnicity, no matter their APOE ε4 allele standing.

Mixed evaluation of WGS and cAD chip information revealed that SNPs rs1890078 (P = 6.64E-07) and rs12594991 (P = 2.03E-07) in SORCS1 and CHD2 genes, respectively, are novel genetic variants amongst APOE ε4 carriers within the Korean inhabitants.

As well as, 9 doable novel variants that have been uncommon in people of European ancestry however frequent in East Asia have been recognized. This examine demonstrates that APOE-stratified evaluation is vital for understanding the genetic background of AD in numerous populations.

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