immune cell infiltration and immune-related genes in the tumor microenvironment

mutationdetection

The impact of chromosomal fusions on 3D genome folding and recombination in the germ line

The spatial folding of chromosomes inside the nucleus has regulatory effects on gene expression, yet the impact of genome reshuffling on this organization remains unclear. Here, we take advantage of chromosome conformation capture in combination with single-nucleotide polymorphism (SNP) genotyping and analysis of crossover events to study how the higher-order chromatin organization and recombination landscapes are affected by chromosomal fusions in the mammalian germ line.

We demonstrate that chromosomal fusions alter the nuclear architecture during meiosis, including an increased rate of heterologous interactions in primary spermatocytes, and alterations in both chromosome synapsis and axis length.

These disturbances in topology were associated with changes in genomic landscapes of recombination, resulting in detectable genomic footprints. Overall, we show that chromosomal fusions impact the dynamic genome topology of germ cells in two ways: (i) altering chromosomal nuclear occupancy and synapsis, and (ii) reshaping landscapes of recombination.

Profiles of immune cell infiltration and immune-related genes in the tumor microenvironment of HNSCC with or without HPV infection

Head and neck squamous cell carcinoma (HNSCC) are the sixth most common cancer type in the world. Human papillomavirus (HPV) infection is an emerging risk factor for HNSCC. Immune infiltration of HNSCC is linked to therapeutic results. This article aimed to decide whether variations in HPV status affect immune infiltration, molecular mechanism, and how these results vary in HNSCC patients.

We investigated the tumor-infiltrating immune cells (TIICs) and immune-related gene differences between HPV (+) and HPV (-) HNSCC. The gene expression quantification data of HNSCC and their clinical information were download from the TCGA database. Immune-related genes have been linked to the ImmPort platform.

After analyzed of 22 TIICs in the HNSCC tumor environment by CIBERSORT and further assessment, lower memory B cell and higher T cell regulatory were connected with better HPV (-) HNSCC outcome, higher activated memory CD4 T cell, higher T cell regulatory, and lower activated NK cell were linked with better HPV (+) result.

We finally got five forms of immune genes (CAMP, EDNRB, NTS, CXCL9, LHB) associated with HNSCC progression. Higher expressions of CAMP, EDNRB, and NTS were associated with increased overall survival in HPV (-) patients. Higher expression of CXCL9 and lower expression of LHB contributed to increased overall survival of HPV (+) patients.

There tend to be discrepancies in the cell structure of TIICs and immune-related genes in HPV (-) and HPV (+) HNSCC. These variances are typically too crucial for the therapeutic outcome of the patient and the development of the tumor. In specific, our sample established these candidate immune cells and immune-related genes as candidate reservoirs for further researches.

mutationdetection
mutationdetection

General Epitestosterone (ET) ELISA Kit

RD-ET-Ge-48Tests 48 Tests
EUR 467

General Epitestosterone (ET) ELISA Kit

RD-ET-Ge-96Tests 96 Tests
EUR 646

IKK-? Kinase Inhibitor II

1811-1
EUR 158

Adenosine Kinase Inhibitor (hydrate)

C5282-1 1 mg
EUR 112
Description: IC50: 1.7 nM in cell-free assaysAdenosine Kinase Inhibitor is an inhibitor of adenosine kinase. Adenosine kinase is the key metabolizing enzyme regulating cellular adenosine concentrations.

Aurora Kinase Inhibitor III

B7947-1 1 mg
EUR 179
Description: Aurora Kinase Inhibitor III

DiscoveryProbe? Kinase Inhibitor Library

L1024-.1 100 uL/well(10 mM solution)
EUR 6267

VEGFR Tyrosine Kinase Inhibitor II

C4603-1 1 mg
EUR 118

DiscoveryProbe? Tyrosine Kinase Inhibitor Library

L1028-.1 100 uL/well(10 mM solution)
EUR 5397

ET-1/ Rat ET- 1 ELISA Kit

ELA-E0482r 96 Tests
EUR 886

Kinase inhibitor-1

HY-43533 5mg
EUR 567

HPGDS inhibitor 1

B1046-1 1 mg
EUR 181
Description: HPGDS inhibitor 1 is an oral potent and selective inhibitor of hematopoietic prostaglandin D synthase (HPGDS) with IC50 value of 0.7nM [1].Prostaglandin D2 (PGD2) is a mediator of allergy and inflammation.

TAO Kinase inhibitor 1

HY-112136 50mg
EUR 796

MAPKII Kinase Inhibitor (Hsp25 Kinase Inhibitor)

SIH-120A 1 mg
EUR 179
  • The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major devel
  • Show more
Description: The substance MAPKII Kinase Inhibitor is a hsp25 kinase inhibitor. It is synthetically produced and has a purity of >95%. The pure substance is white solid which is soluble in DMSO or H20.

ET-1 Polyclonal Antibody

41562-100ul 100ul
EUR 252

ET-1 Polyclonal Antibody

41562-50ul 50ul
EUR 187

ET-1 Polyclonal Antibody

ABP52878-003ml 0.03ml
EUR 158
  • Immunogen information: Synthesized peptide derived from the Internal region of human ET-1
  • Applications tips:
Description: A polyclonal antibody for detection of ET-1 from Human. This ET-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ET-1

ET-1 Polyclonal Antibody

ABP52878-01ml 0.1ml
EUR 289
  • Immunogen information: Synthesized peptide derived from the Internal region of human ET-1
  • Applications tips:
Description: A polyclonal antibody for detection of ET-1 from Human. This ET-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ET-1

ET-1 Polyclonal Antibody

ABP52878-02ml 0.2ml
EUR 414
  • Immunogen information: Synthesized peptide derived from the Internal region of human ET-1
  • Applications tips:
Description: A polyclonal antibody for detection of ET-1 from Human. This ET-1 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ET-1

ET-1 Polyclonal Antibody

ES3877-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against ET-1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

ET-1 Polyclonal Antibody

ES3877-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against ET-1 from Human. This antibody is tested and validated for WB, ELISA, WB, ELISA

Anti-ET-1 antibody

STJ96512 200 µl
EUR 197
Description: Rabbit polyclonal to ET-1.

Endothelin 1 (ET-1) Antibody

abx024086-100ug 100 ug
EUR 940
  • Shipped within 5-10 working days.

Sorafenib (Raf-1 kinase inhibitor)

SIH-476-10MG 10 mg
EUR 121
  • Sorafenib display inhibition of multiple kinase targets including, VEGFR, PDGFR, and Raf.
Description: The substance Sorafenib is a raf-1 kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is off white powder which is soluble inDMSO (200mg/ml) or ethanol (3mg/ml).

Sorafenib (Raf-1 kinase inhibitor)

SIH-476-50MG 50 mg
EUR 289
  • Sorafenib display inhibition of multiple kinase targets including, VEGFR, PDGFR, and Raf.
Description: The substance Sorafenib is a raf-1 kinase inhibitor. It is synthetically produced and has a purity of >99%. The pure substance is off white powder which is soluble inDMSO (200mg/ml) or ethanol (3mg/ml).

187-1, N-WASP inhibitor

B5251-1 1 mg
EUR 399

p16-INK4a Cyclin-Dependent Kinase Inhibitor 2A Human Recombinant Protein

PROTP42771-1 Regular: 20ug
EUR 317
Description: CDKN2A Human Recombinant produced in E.Coli, it's a single non-glycosylated polypeptide chain containing 156 amino acids, approximately 16.5 kDa.;CDKN2A is purified by proprietary chromatographic techniques.

Human ET-1 ELISA Kit

EHE0184 96Tests
EUR 521

Canine ET-1 ELISA Kit

ELA-E0482d 96 Tests
EUR 928

Goat ET-1 ELISA Kit

EGTE0184 96Tests
EUR 521

Bovine ET-1 ELISA Kit

EBE0184 96Tests
EUR 521

Canine ET-1 ELISA Kit

ECE0184 96Tests
EUR 521

Anserini ET-1 ELISA Kit

EAE0184 96Tests
EUR 521

ET-1 Polyclonal Conjugated Antibody

C41562 100ul
EUR 397

Mouse ET-1 ELISA Kit

EME0184 96Tests
EUR 521

Rat ET-1 ELISA Kit

ERE0184 96Tests
EUR 521

Rabbit ET-1 ELISA Kit

ERTE0184 96Tests
EUR 521

Porcine ET-1 ELISA Kit

EPE0184 96Tests
EUR 521

ET-1(Endothelin-1) ELISA Kit

EU0205 96T
EUR 524.1
  • Detection range: 1.25-80 pg/ml
Description: Method of detection: Coated with Antigen, Competitive ELISA;Reacts with: General;Sensitivity: 0.625pg/ml

Tie2 Kinase Inhibitor

B1338-25
EUR 756

Tie2 Kinase Inhibitor

B1338-5
EUR 262

MAPKII Kinase Inhibitor

abx076811-1mg 1 mg
EUR 314
  • Shipped within 5-12 working days.

Tie2 kinase inhibitor

E1KS1577 10mg
EUR 1541

Tie2 kinase inhibitor

A5979-100 100 mg
EUR 1210
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor

A5979-25 25 mg
EUR 398
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor

A5979-5 5 mg
EUR 166
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

Tie2 kinase inhibitor

A5979-5.1 10 mM (in 1mL DMSO)
EUR 447
Description: IC50: A reversible and selective inhibitor of Tie2 with IC50 of 0.25 M, whose selectivity is 200-fold higher than that of p38.

AKT Kinase Inhibitor

A3150-10 10 mg
EUR 1136
Description: AKT Kinase Inhibitor

AKT Kinase Inhibitor

A3150-5 5 mg
EUR 683
Description: AKT Kinase Inhibitor

AKT Kinase Inhibitor

A3150-5.1 10 mM (in 1mL DMSO)
EUR 746
Description: AKT Kinase Inhibitor

AKT Kinase Inhibitor

HY-10249A 10mg
EUR 877

Tyrosine kinase inhibitor

HY-10421 25mg
EUR 383

Dasatinib (Kinase inhibitor)

SIH-440-25MG 25 mg
EUR 199
  • Dasatinib is a dual Src and Abl kinase inhibitor with ?325 times more potency against BCR-ABL than imatinib. Specifically, it inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner.
Description: The substance Dasatinib is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is crystalline solid which is soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ).

Dasatinib (Kinase inhibitor)

SIH-440-5MG 5 mg
EUR 134
  • Dasatinib is a dual Src and Abl kinase inhibitor with ?325 times more potency against BCR-ABL than imatinib. Specifically, it inhibits autophosphorylation and substrate phosphorylation in a concentration-dependent manner.
Description: The substance Dasatinib is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is crystalline solid which is soluble in DMSO (200 mg/ml), ethanol (very poorly ), and water (very poorly ).

K252A (Kinase inhibitor)

SIH-455-100UG 100 µg
EUR 131
  • K252A is a non-selective protein kinase inhibitor that exhibits a wide range of effects. Specifically, it has been seen to inhibit PKA, PKC, PKG, CAM kinase II, mlCK, Ser/Thr kinase, Met, and receptor tyrosine kinases. It has been shown to prevent au
  • Show more
Description: The substance K252A is a kinase inhibitor. It is nonomuraea longicatena and has a purity of ?98%. The pure substance is white solid which is soluble to 25 mM in DMSO.

K252A (Kinase inhibitor)

SIH-455-1MG 1 mg
EUR 299
  • K252A is a non-selective protein kinase inhibitor that exhibits a wide range of effects. Specifically, it has been seen to inhibit PKA, PKC, PKG, CAM kinase II, mlCK, Ser/Thr kinase, Met, and receptor tyrosine kinases. It has been shown to prevent au
  • Show more
Description: The substance K252A is a kinase inhibitor. It is nonomuraea longicatena and has a purity of ?98%. The pure substance is white solid which is soluble to 25 mM in DMSO.

K252B (Kinase inhibitor)

SIH-456-100UG 100 µg
EUR 182
  • K252B is a non-selective, protein kinase inhibitor. It inhibits CaMKII, MYLK, PKA, PKC, and cGKI. It acts by binding to the ATP binding domain of the kinase. K252B is cell permeable.
Description: The substance K252B is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml).

K252B (Kinase inhibitor)

SIH-456-1MG 1 mg
EUR 569
  • K252B is a non-selective, protein kinase inhibitor. It inhibits CaMKII, MYLK, PKA, PKC, and cGKI. It acts by binding to the ATP binding domain of the kinase. K252B is cell permeable.
Description: The substance K252B is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white solid which is soluble in DMSO (1 mg/ml) or dimethyl formamide (1 mg/ml).

Midostaurin (Kinase inhibitor)

SIH-468-1MG 1 mg
EUR 171
  • Midostaurin is a broad spectrum protein kinase inhibitor. It also shows inhibition of PKC?, PKC? and PKC? isoforms, Flk, and c-kit. Midostaurin displays antiproliferative characteristics and the ability to induce apoptosis.
Description: The substance Midostaurin is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white powder which is soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml).

Midostaurin (Kinase inhibitor)

SIH-468-5MG 5 mg
EUR 507
  • Midostaurin is a broad spectrum protein kinase inhibitor. It also shows inhibition of PKC?, PKC? and PKC? isoforms, Flk, and c-kit. Midostaurin displays antiproliferative characteristics and the ability to induce apoptosis.
Description: The substance Midostaurin is a kinase inhibitor. It is synthetically produced and has a purity of ?98%. The pure substance is white to off-white powder which is soluble in DMSO (15 mg/ml), MDC (10 mg/ml), methanol (5 mg/ml) or 100% ethanol (2.5 mg/ml).

Big ET/ Rat Big ET ELISA Kit

ELA-E0483r 96 Tests
EUR 886

YAP-TEAD Inhibitor 1 (Peptide 17)

A1149-1 1 mg
EUR 235

p21/Cyclin-Dependent Kinase Inhibitor 1

MO47036 100 ul
EUR 349

Chk2 Inhibitor

1702-1
EUR 180

SCD1 Inhibitor

1716-1
EUR 218

ACC2 Inhibitor

1717-1
EUR 218

Syk Inhibitor

1983-1
EUR 126

Stat5 Inhibitor

9484-1
EUR 120

EGFR Inhibitor

C3327-1 1 mg
EUR 154
Description: EGFR inhibitor is a cell permeable, pyrimidine compound that selectively inhibits the EGFR kinase with IC50 value of 21 nM [1]. EGFR is a transmembrane protein, and is a receptor for members of epidermal growth factor family.

Lck Inhibitor

A3539-1 1 mg
EUR 154
Description: Lck Inhibitor is a small-molecule inhibitor of with IC50 value of 7 nM [1].The lymphocyte specific kinase which expressed in NK cells and T-cells is a member of the Src kinase family.

NFAT Inhibitor

A4539-1 1 mg
EUR 138
Description: Selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT). Does not disrupt other calcineurin-dependent pathways. Inhibits NFAT activation and NFAT-dependent expression of endogenous cytokine genes in T cells.

Phosphatase Inhibitor Cocktail 1 (100X in DMSO)

K1012-1 1 ml
EUR 102

ET-3 antibody

22579-100ul 100ul
EUR 390

ET-2 Antibody

35400-100ul 100ul
EUR 390

human Endothelin 1,ET-1 ELISA Kit

201-12-1239 96 tests
EUR 440
  • This Endothelin 1 ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Mouse Endothelin 1, ET-1 ELISA Kit

CSB-E05145m-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Mouse Endothelin 1, ET-1 in samples from serum, plasma, cell culture supernates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Endothelin 1, ET-1 ELISA Kit

1-CSB-E05145m
  • EUR 946.00
  • EUR 5782.00
  • EUR 3060.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Mouse Endothelin 1, ET-1 in samples from serum, plasma, cell culture supernates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Pig endothelin 1, ET-1 ELISA Kit

CSB-E06806p-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Pig endothelin 1, ET-1 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Pig endothelin 1, ET-1 ELISA Kit

1-CSB-E06806p
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Pig endothelin 1, ET-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Endothelin 1 (ET-1) CLIA Kit

abx195560-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Mouse Endothelin 1 (ET-1) CLIA Kit

abx195561-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Rat Endothelin 1 (ET-1) CLIA Kit

abx195562-96tests 96 tests
EUR 825
  • Shipped within 5-12 working days.

Rabbit Endothelin 1,ET-1 ELISA Kit

CN-00693R1 96T
EUR 455

Rabbit Endothelin 1,ET-1 ELISA Kit

CN-00693R2 48T
EUR 304

Canine Endothelin 1,ET-1 ELISA Kit

CN-00955C1 96T
EUR 444

Canine Endothelin 1,ET-1 ELISA Kit

CN-00955C2 48T
EUR 294

PoFAine endothelin 1,ET-1 ELISA Kit

CN-01235P1 96T
EUR 439

PoFAine endothelin 1,ET-1 ELISA Kit

CN-01235P2 48T
EUR 290

Rabbit Endothelin 1, ET-1 ELISA Kit

CSB-E06951Rb-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Rabbit Endothelin 1, ET-1 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Rabbit Endothelin 1, ET-1 ELISA Kit

1-CSB-E06951Rb
  • EUR 967.00
  • EUR 5925.00
  • EUR 3134.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Rabbit Endothelin 1, ET-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

rat Endothelin 1, ET-1 ELISA Kit

CSB-E06979r-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring rat Endothelin 1, ET-1 in samples from serum, plasma, cell lysates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

rat Endothelin 1, ET-1 ELISA Kit

1-CSB-E06979r
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring rat Endothelin 1, ET-1 in samples from serum, plasma, cell lysates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Dog Endothelin 1, ET-1 ELISA Kit

CSB-E07002c-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Dog Endothelin 1, ET-1 in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Dog Endothelin 1, ET-1 ELISA Kit

1-CSB-E07002c
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Dog Endothelin 1, ET-1 in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Endothelin 1, ET-1 ELISA Kit

CSB-E07007h-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Endothelin 1, ET-1 in samples from serum, cell culture supernates, urine, saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Endothelin 1, ET-1 ELISA Kit

1-CSB-E07007h
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human Endothelin 1, ET-1 in samples from serum, cell culture supernates, urine, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Endothelin 1,ET-1 ELISA Kit

CN-01966R1 96T
EUR 467

Multi-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage

The evolutionary pressure of endemic malaria and other erythrocytic pathogens has shaped variation in genes encoding erythrocyte structural and functional proteins, influencing responses to hemolytic stress during transfusion and disease.

We sought to identify such genetic variants in blood donors by conducting a genome-wide association study (GWAS) of 12,353 volunteer donors, including 1,483 African Americans, 1,477 Asians, and 960 Hispanics, whose stored erythrocytes were characterized by quantitative assays of in vitro osmotic, oxidative, and cold-storage hemolysis.

GWAS revealed 27 significant loci (p<5×10-8), many in candidate genes known to modulate erythrocyte structure, metabolism, and ion channels, including SPTA1, ALDH2, ANK1, HK1, MAPKAPK5, AQP1, PIEZO1, and SLC4A1/Band 3. GWAS of oxidative hemolysis identified variants in antioxidant enzymes including GLRX, GPX4, G6PD, and a novel golgi-transport protein SEC14L4.

Genome wide significant loci were also tested for association with the severity of steady state (baseline) in vivo hemolytic anemia in patients with sickle cell disease, with confirmation of identified SNPs in HBA2, G6PD, PIEZO1, AQP1 and SEC14L4. Many of the identified variants, such as those in G6PD, have previously been shown to impair erythrocyte recovery after transfusion, associate with anemia, or cause rare Mendelian human hemolytic diseases.

Candidate SNPs in these genes, especially in polygenic combinations, may affect RBC recovery after transfusion and modulate disease severity in hemolytic diseases, such as sickle cell disease and malaria.

Incorporating Genomic and Genetic Testing into the Treatment of Metastatic Luminal Breast Cancer

Background: Treatment of patients with luminal metastatic breast cancer (MBC) has become even more complex over the last few years as molecular profiling has begun to alter disease management. It is well accepted that MBC is not curable but is treatable. Today we are able to prolong progression-free survival and partly overall survival with targeted and more individual treatment strategies adjusted according to the molecular subtype.

Summary: Genetic and genomic testing has become therapeutically relevant in luminal MBC and is therefore an integral component within the treatment spectrum. By now, germline testing of BRCABRCAPIK3CA mutations are inevitable elements in disease management and the current state of the art in luminal MBC patients.

Furthermore, testing of ESR1 resistance mutation, ERBB2 mutation, microsatellite instability, and neurotrophic tyrosine receptor kinase (NTRK) gene fusion (mainly in secretory breast cancer) has recently gained increasing attention. However, based on the expanding role of personalized medicine, clinicians are now faced with substantial new challenges and possibly unsuspected possibilities. The following review summarizes current developments in genetic and genomic testing in luminal MBC.

 

Key messages: In luminal MBC genomics have become an integral component within the spectrum of oncological treatment establishing novel therapeutic facilities. Further developments in treatment personalization adjusted according to the molecular subtype should become increasingly important in order to enhance the progress of de-escalation of chemotherapy in luminal MBC. However, based on the expanding role of personalized medicine, clinicians are now faced with substantial new challenges and possibly unsuspected possibilities.

HIV-P24 antigen array kit

VArk-Lsx001 unit Ask for price
Description: Fourth-generation HIV immunoassays detect viral p24 protein in the blood.

HIV-1 GAG P24 Recombinant Antigen

00111-V-01mg 0,1 mg
EUR 267.5
  • Category: Antigens, HIV-1/HIV-2, Ag
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV-1 GAG P24 Recombinant Antigen

00111-V-1000ug 1000 ug
EUR 1282.5
  • Category: Antigens, HIV-1/HIV-2, Ag
Description: HIV-1 gag p24 recombinant antigen a.a 77 to a.a 436 of the HIV-1 gag region 39 kDa

HIV 1 p24 core recombinant antigen

00177-V-01mg 0,1 mg
EUR 267.5
  • Category: Antigens, HIV-1/HIV-2, Ag
Description: HIV 1 p24 core recombinant antigen.

HIV 1 p24 core recombinant antigen

00177-V-1000ug 1000 ug
EUR 1282.5
  • Category: Antigens, HIV-1/HIV-2, Ag
Description: HIV 1 p24 core recombinant antigen.

HIV-1 p24 ELISA Kit

Z7040001 1 kit
EUR 812
Description: Premade ready to use kits will always come in handy. Get your experiment done right form the first try by using a validated kit with perfectly balanced reagents proportions and compatibility and by following a clear protocol.

HIV-1 p24

E5-00024 1mg
EUR 960

HIV-1 p24

E62H002 100ug
EUR 382

HIV Type 1 p24 Antigen ELISA (96 Determinations)

0801111 96T
EUR 548.16
  • What is the product classification?
  • HIV Type 1 p24 Antigen ELISA is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

HIV Type 1 p24 Antigen ELISA 2.0 (96 Determinations)

0801002 96T
EUR 548.16
  • What is the product classification?
  • HIV Type 1 p24 Antigen ELISA 2.0 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

Recombinant HIV-1 p24

7-07603 100µg Ask for price

Recombinant HIV-1 p24

7-07604 500µg Ask for price

Recombinant HIV-1 p24

7-07605 1000µg Ask for price

HIV-1 Gag p24

05-005 50 ug
EUR 362
Description: The HIV-1 Gag p24 is available in Europe and for worldwide shipping via Gentaur.

HIV-1 Gag p24

05-006 250 ug
EUR 962
Description: The HIV-1 Gag p24 is available in Europe and for worldwide shipping via Gentaur.

HIV type 1 P24

DAG1520 100 µg
EUR 810

HIV-1 p24 Antibody

abx023027-1ml 1 ml
EUR 578
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

abx023925-1mg 1 mg
EUR 690
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

abx023926-1mg 1 mg
EUR 690
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

abx021869-1mg 1 mg
EUR 662
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

abx021870-1mg 1 mg
EUR 634
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

abx021871-1mg 1 mg
EUR 662
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

abx021872-1mg 1 mg
EUR 662
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

abx021873-1mg 1 mg
EUR 662
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

abx021882-1mg 1 mg
EUR 982
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

abx021883-1mg 1 mg
EUR 1017
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

abx021886-1mg 1 mg
EUR 1017
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

abx021887-1mg 1 mg
EUR 1017
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

abx021888-1mg 1 mg
EUR 1017
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody

20-abx137062
  • EUR 356.00
  • EUR 523.00
  • 0.5 mg
  • 1 mg
  • Shipped within 5-10 working days.

HIV-1 p24 Protein

abx169032-1mg 1 mg
EUR 551
  • Shipped within 5-10 working days.

HIV-1, p24 Protein

abx069857-1mg 1 mg
EUR 1574
  • Shipped within 5-10 working days.

HIV 1 p24 Protein

abx060589-1mg 1 mg
EUR 1288
  • Shipped within 5-10 working days.

HIV-1 p24 Protein

abx061424-05mg 0.5 mg
EUR 739
  • Shipped within 5-10 working days.

HIV-1 p24 Protein

20-abx261886
  • EUR 4490.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

p24-HIV(p24/661) Antibody

BNUB0661-100 100uL
EUR 209
Description: Primary antibody against p24-HIV(p24/661), Concentration: 0.2mg/mL

p24-HIV(p24/661) Antibody

BNUB0661-500 500uL
EUR 458
Description: Primary antibody against p24-HIV(p24/661), Concentration: 0.2mg/mL

p24-HIV(p24/661) Antibody

BNUM0661-50 50uL
EUR 395
Description: Primary antibody against p24-HIV(p24/661), 1mg/mL

p24-HIV(p24/661) Antibody

BNC040661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF405S conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC040661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF405S conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC550661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF555 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC550661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF555 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC610661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF660R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC610661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF660R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC470661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF647 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC470661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF647 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC050661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF405M conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC050661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF405M conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC400661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF640R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC400661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF640R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC430661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF543 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC430661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF543 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC800661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF680 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC800661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF680 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCP0661-250 250uL
EUR 383
Description: Primary antibody against p24-HIV(p24/661), PerCP conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCR0661-250 250uL
EUR 383
Description: Primary antibody against p24-HIV(p24/661), RPE conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCA0661-250 250uL
EUR 383
Description: Primary antibody against p24-HIV(p24/661), APC conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCAP0661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCAP0661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCB0661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), Biotin conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCB0661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), Biotin conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCH0661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNCH0661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC940661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF594 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC940661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF594 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC680661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF568 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC680661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF568 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC700661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF770 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC700661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF770 conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC880661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF488A conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC880661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF488A conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC810661-100 100uL
EUR 199
Description: Primary antibody against p24-HIV(p24/661), CF680R conjugate, Concentration: 0.1mg/mL

p24-HIV(p24/661) Antibody

BNC810661-500 500uL
EUR 544
Description: Primary antibody against p24-HIV(p24/661), CF680R conjugate, Concentration: 0.1mg/mL

HIV p24 Antibody

abx021867-1mg 1 mg
EUR 1344
  • Shipped within 5-10 working days.

HIV p24 Antibody

abx021868-1mg 1 mg
EUR 1344
  • Shipped within 5-10 working days.

Human(HIV-P24)

QY-E05679 96T
EUR 361

HIV Type 1 p24 Antigen ELISA (5 X 96 Determinations)

0801200 5 X 96T
EUR 2119.6
  • What is the product classification?
  • HIV Type 1 p24 Antigen ELISA is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

Recombinant HIV-1 p24 Core

7-07597 100µg Ask for price

Recombinant HIV-1 p24 Core

7-07598 500µg Ask for price

Recombinant HIV-1 p24 Core

7-07599 1000µg Ask for price

Recombinant HIV-1 p24 , 24kDa

7-07621 2µg Ask for price

Recombinant HIV-1 p24 , 24kDa

7-07622 10µg Ask for price

Recombinant HIV-1 p24 , 24kDa

7-07623 100µg Ask for price

HIV type 1 P24 [GST]

DAG1516 100 µg
EUR 645

HIV type 1 P24 [His]

DAG1518 100 µg
EUR 645

HIV type 1 P24 [Biotin]

DAG1519 100 µg
EUR 810

HIV type 1 P24 [His]

DAG1799 50 ug
EUR 1681

HIV type 1 P24 [His]

DAG2375 100 µg
EUR 724

HIV type 1 P24 [His]

DAG2377 100 µg
EUR 724

HIV type 1 p24 [FITC]

DAGH004 50 Tests
EUR 927

HIV-1 p24 Antibody (FITC)

abx023026-1ml 1 ml
EUR 565
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody (Biotin)

abx023028-1ml 1 ml
EUR 662
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody (HRP)

abx023029-1ml 1 ml
EUR 739
  • Shipped within 5-10 working days.

HIV 1 / 2 p24 Antibody

abx021866-1mg 1 mg
EUR 1010
  • Shipped within 5-10 working days.

HIV-1 p24 Antibody (FITC)

abx021884-100ug 100 ug
EUR 739
  • Shipped within 5-10 working days.

 

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